报告题目：生物钟与环境适应性调控

报告人 ：徐小冬

报告时间：2018年1月30日15:00-16:00

报告地点：植物逆境生物学重点实验室301会议室

主办单位：植物逆境生物学重点实验室

欢迎光临！

徐小冬 博士，1996 年 8 月毕业于河北师范大学生物系，生物教育专业，理学学士学位；2002 年 8 月毕业于河北师范大学生命科学学院细胞生物学专业，理学博士学位，师从马力耕教授和孙大业院士。2002 年底起赴美，先后在美国 Vanderbilt University (Carl H. Johnson’s Lab 2002-2006),Dartmouth College (C. Robertson McClung’s Lab 2006-2010) 做博士后（Postdoc. & ResearchAssociate）研究，研究领域均为生物钟 (Circadian Clock)/时间生物学 (Chronobiology) 。2010 年起任河北师范大学特聘教授，“细胞生物学国家重点学科”人才引进，博士生导师，任职于生命科学学院、教育部分子细胞学重点实验室、河北省分子细胞生物学重点实验室，细胞生物学教研室主任，“生物节律”课题组长，时间生物学研究平台负责人，从事科研、教学、博/硕士研究生指导工作，研究方向为生物钟与组织稳态调控。教育部“新世纪优秀人才支持计划”(2014.01-2016.12) 项目批准号 NCET-13-0771。河北省教育厅“百名优秀创新人才支持计划”(2011-2013)项目批准号 CPRC036，（2013年结题验收考核成绩优秀）。

研究成果发表部分 ( 主要研究论文、参编书籍):

1. Wang, P., Cui, X., Zhao, C., Shi, L., Zhang, G., Sun, F., Cao, X., Yuan, L., Xie, Q., and Xu, X. (2017). COR27 and COR28 encode nighttime repressors integrating Arabidopsis circadian clock and cold response. J Integr Plant Biol 59, 78-85. (通讯作者)

2. Zhang, B., Wang, X., Zhao, Z., Wang, R., Huang, X., Zhu, Y., Yuan, L., Wang, Y., Xu, X.,Burlingame, A.L., Gao, Y., Sun, Y., and Tang, T. (2015) OsBRI1 activates BR signaling by preventing binding between the TPR and kinase domains of OsBSK3 via phosphorylation.Plant Physiology 170, 1149-1161.

3. 谢启光，徐小冬(2015) 植物生物钟与关键农艺性状调控, 《生命科学》 27(11): 1336-1344. (专题综述) (通讯作者)

4. Xing, H., Wang, P., Cui, X., Wang, L., Zhang, C., Liu, X., Yuan, L., Li, Y., Xie, Q., and Xu, X.(2015). LNK1 and LNK2 recruitment to the evening element require morning expressed circadian related MYB-like transcription factors. Plant Signaling & Behavior,10(3):e1010888. doi: 10.1080/15592324.2015.1010888. (通讯作者)

5. Xie, Q., Wang, P., Liu, X., Yuan, L., Wang, L., Zhang, C., Li, Y., Xing, H., Zhi, L., Yue, Z., Zhao,C., McClung, C.R., and Xu, X. (2014). LNK1 and LNK2 are transcriptional coactivators in

the Arabidopsis circadian oscillator. Plant Cell 26, 2843-2857. (通讯作者) 6. Cui, X., Lu, F., Li, Y., Xue, Y., Kang, Y., Zhang, S., Qiu, Q., Cui, X., Zheng, S., Liu, B., Xu, X., and Cao, X. (2013). Ubiquitin-specific proteases UBP12 and UBP13 act in circadian clock and photoperiodic flowering regulation in Arabidopsis. Plant Physiol 162, 897-906. （合作研究）

7. 徐小冬, 谢启光 (2013) 植物生物钟研究的历史回顾与最新进展, 自然杂志 Chinese Journal of Nature 35(2): 118-126. (专题综述) (通讯作者)

8. Wang X, Wu F, Xie Q, Wang H, Wang Y, Yue Y, Gahura O, Ma S, Liu L, Cao Y, Jiao Y, Puta F,McClung CR, Xu X, Ma L (2012) SKIP Is a Component of the Spliceosome Linking Alternative Splicing and the Circadian Clock in Arabidopsis. Plant Cell 24, 3278-3295.（合作成果）

9. Xie, Q., Soutto, M., Xu, X., Zhang, Y. and Johnson, C. H. (2011) Bioluminescence resonance energy transfer (BRET) imaging in plant seedlings and mammalian cells, Methods Mol Biol 680: 3-28.

10. Lou, P.*, Xie, Q.*, Xu, X.*, Edwards, C. E., Brock, M. T., Weinig, C. and McClung, C. R. (2011) Genetic architecture of the circadian clock and flowering time in Brassica rapa, Theor Appl Genet 123(3): 397-409. *co-first author.

11. Edwards, C. E., Ewers, B. E., Williams, D. G., Xie, Q., Lou, P., Xu, X., McClung, C. R. And Weinig, C. (2011) The genetic architecture of ecophysiological and circadian traits in Brassica rapa, Genetics 189(1): 375-90.

12. Xu X, Xie Q, & McClung CR (2010) Robust circadian rhythms of gene expression in Brassica rapa tissue culture. Plant Physiol 153(2):841-850.

13. Xu, X., Graeff, R., Xie, Q., Gamble, K.L., Mori, T., and Johnson, C.H. (2009). Comment on "The Arabidopsis circadian clock incorporates a cADPR-based feedback loop". Science.326, 230.

14. Hotta CT *, Xu X*, Xie Q, Dodd AN, Webb AAR and Johnson CH. (2008) Are there multiple circadian clocks in plants? Plant Signaling & Behavior 5, 342-344.* co-first author.

15. Gutiérrez R.A., Stokes T.L., Thum K., Xu X., Obertello M., Katari M.S., Tanurdzic M., Dean A., Nero D.C., McClung C.R. and Coruzzi G.M. (2008) Systems approach identifies an organic nitrogen-responsive gene network that is regulated by the master clock control gene CCA1. Proc Natl Acad Sci U S A. 105, 4939-4944.

16. Xu X, Hotta CT, Dodd AN, Love J, Sharrock R, Lee YW, Xie Q, Johnson CH, Webb AA.. (2007) Distinct Light and Clock Modulation of Cytosolic Free Ca 2+ Oscillations and Rhythmic CHLOROPHYLL A/B BINDING PROTEIN2 Promoter Activity in Arabidopsis. Plant Cell. 19, 3474-3490.

17. Wu Y, Xu X, Li S, Liu T, Ma L, Shang Z. (2007) Heterotrimeric G-protein participation in Arabidopsis pollen germination through modulation of a plasmamembrane hyperpolarization-activated Ca 2+ -permeable channel. New Phytol. 176, 550-559.

18. Xu X, Soutto M, Xie Q, Servick S, Subramanian C, von Arnim AG, Johnson CH. (2007) Imaging protein interactions with bioluminescence resonance energy transfer (BRET) in plant and mammalian cells and tissues. Proc Natl Acad Sci U S A. 104, 10264-9.

19. Subramanian C., Woo J., Cai X., Xu X., Servick S., Johnson C.J., Nebenfülu A., von Arnim AG. (2006) A suite of tools and application notes for in vivo protein interaction assays using bioluminescence resonance energy transfer (BRET). Plant Journal. 48, 138-152.

20. Subramanian C, Kim BH, Lyssenko NN, Xu X, Johnson CH, von Arnim AG (2004) The Arabidopsis repressor of light signaling, COP1, is regulated by nuclear exclusion: mutational analysis by bioluminescence resonance energy transfer. Proc. Natl. Acad. Sci.个人简历(curriculum vitae) USA 101, 6798-6802.

21. Ma LG, Xu XD, Cui SJ，Sun DY. (1999) The presence of a heterotrimeric G protein and its role in signal transduction of extracellular calmodulin in pollen germination and tube growth. Plant Cell 11, 1351-1363.

22. Xu XD, Ma LG, Sun Y, Sun DY. (1999) Activation effect of extracellular calmodulin on heterotrimeric G protein in pollen plasma membrane. Chinese Science Bulletin 44,190-191.

23. 徐小冬 （2001）脱落酸作用的信号转导机理. “细胞信号转导(第三版)” 孙大业,郭艳林,马力耕 编著. 科学出版社, 319-332.