郝福顺,男,博士,教授,河南大学特聘教授,博士生导师,河南省教育厅学术技术带头人,棉花生物学国家重点实验室及植物逆境生物学重点实验室科研骨干。1990年本科毕业于山西师范大学,1993年毕业于山东师范大学,获硕士学位,2005年获中国农业大学博士学位。近年来主持国家自然科学基金5项,主持农业部转基因新品种培育科技重大专项课题1项、参与973国家重点基础发展规划项目2项。在重要学术刊物上发表文章30余篇,出版专著1部,参编著作2部,参与翻译著作1部。
研究方向:植物逆境胁迫响应及生长发育分子机制
(1)脱落酸及活性氧信号调控植物生长发育及逆境胁迫响应的分子机制
脱落酸(ABA)和信号分子活性氧(ROS)在调控植物发育、气孔运动和逆境胁迫响应中发挥重要作用,但其具体的调控机制仍需深入研究。我们以拟南芥为材料,利用细胞、生化和分子生物学新技术,深入研究植物生命活动过程中ABA、ROS与其他信号的互作机制及其下游目标,揭示ABA和ROS新的作用机制及调控途径。
(2)棉花功能基因组学和表观遗传修饰机制研究
棉花是重要的经济作物,调控其生长发育和胁迫应答的功能基因及其作用机制目前尚缺乏深入研究。我们主要利用生理、细胞、分子及各种组学技术研究棉花应答低钾、高温胁迫机制及染色质表观遗传修饰调控逆境响应和棉纤维发育的机制,筛选差异表达蛋白,克隆棉花重要功能基因,通过转基因技术研究其在棉花逆境适应和生长发育中的作用及机制,为提高棉花产量品质和耐逆性奠定基础。
主持的主要科研项目:
(1)GhCIPK23调控棉花响应缺钾胁迫的作用机制研究(32072108),国家自然科学基金面上项目,2021.01-2024.12;
(2)拟南芥E3泛素连接酶ATL17调控脱落酸抑制主根生长的分子机制研究(31870248),国家自然科学基金面上项目,2019.01-2022.12;
(3)AtSSM1介导的活性氧信号调控盐胁迫下拟南芥钾钠离子平衡机制研究(31070239),国家自然科学基金面上项目,2011.01-2013.12;
(4)活性氧相关基因AtODSl在拟南芥缺氧应答反应中的功能研究(30970235),国家自然科学基金面上项目,2010.01-2012.12;
(5)pH信号在保卫细胞ABA、H2O2和NO信号转导中的作用机制分析(30670183),国家自然科学基金面上项目,2007.01-2009.12;
(6)抗旱耐盐转基因玉米新品种培育(2009ZX08003-008B),转基因生物新品种培育科技重大专项,2009.07-2010.12;
(7)玉米优良自交系转基因高效转化体系建立及抗旱新品系培育(2011HASTIT007);河南省高校科技创新人才支持计划项目,2011.01-2012.12;
(8)穿膜肽介导的棉花花粉管通道法高效遗传转化体系建立(162102110005),河南省科技厅科技攻关计划项目,2016.01-2017.12;
(9)AtNADK2调控脱落酸诱导气孔关闭机制研究(17A180018),河南省教育厅科学技术研究重点项目,2016.01-2018.12。
代表论文与著作:
1. Wang Y, Zhao ZJ, Liu F, Sun LR,* Hao FS*. Versatile roles of aquaporins in plant growth and development. International Journal of Molecular Science. 2020, 21(24): 9485.
2. Saravana Kumar RM, Wang YB, Zhang XP, Cheng H, Sun LR, He SB*, Hao FS*. Redox components: key regulators of epigenetic modifications in plants. International Journal of Molecular Science. 2020, 21, 1419.
3. Zhang GF, Yue CM, Lu TT, Sun LR, Hao FS*. Genome-wide identification and expression analysis of NADPH oxidase genes in response to ABA and abiotic stresses, and in fibre formation in Gossypium. PeerJ, 2020, 8: e8404.
4. Zhang XP, Ma CX, Sun LR, Hao FS*. Roles and mechanisms of Ca2+ in regulating primary root growth of plants. Plant Signaling & Behavior, 2020, 15: 5, 1748283.
5. Lu TT, Zhang GF, Wang YB, He SB, Sun LR, Hao FS*. Genome-wide characterization and expression analysis of PP2CA family members in response to ABA and osmotic stress in Gossypium. PeerJ, 2019, 7:e7105.
6. Sun LR, Zhao ZJ, Hao FS*. NADPH oxidases, essential players of hormone signalings in plant development and response to stresses. Plant Signaling & Behavior, 2019, 14(11): e1657343.
7. Sun LR, Yue CM, Hao FS*. Update on roles of nitric oxide in regulating stomatal closure. Plant Signaling & Behavior, 2019, 14(10): e1649569.
8. Sun LR, Xu YX, Bai SL, Bai X, Zhu HJ, Dong H, Wang W, Zhu XH, Hao FS, Song CP*. Transcriptome-wide analysis of pseudouridylation of mRNA and non-coding RNAs in Arabidopsis. Journal of Experimental Botany. 2019. 70 (19): 5089–5100.
9. Zhang JX, Wang FR, Zhang CY, Zhang JH, Chen Y, Liu GD, Zhao YX, Hao FS*, Zhang J*. A novel VIGS method by agroinoculation of cotton seeds and application for elucidating functions of GhBI-1 in salt-stress response. Plant Cell Reports, 2018, 37(8): 1091-1100.
10. Pang YQ, Li JT, Qi BS, Tian M, Sun LR, Wang XC, Hao FS*. Aquaporin AtTIP5;1 as an essential target of gibberellins promotes hypocotyl cell elongation in Arabidopsis thaliana under excess boron stress. Functional Plant Biology, 2018, 45(3): 305-314.
11. Sun LR, Wang YB, He SB, Hao FS*. Mechanisms for abscisic acid inhibition of primary root growth. Plant Signaling & Behavior, 2018, 13: 9, e1500069.
12. Sun LR, Ma LY, He SB, Hao FS*. AtrbohD functions downstream of ROP2 and positively regulates waterlogging response. Plant Signaling & Behavior, 2018, 13: 9, e1513300.
13. Sun LR, Li YP, Miao WW, Piao TT, Hao Y, Hao FS*. NADK2 positively modulates abscisic acid-induced stomatal closure by affecting accumulation of H2O2, Ca2+ and nitric oxide in Arabidopsis guard cells. Plant Science, 2017, 262: 81-90.
14. Liu B, Sun LR, Ma LY, Hao FS*. Both AtrbohD and AtrbohF are essential for mediating responses to oxygen deficiency in Arabidopsis. Plant Cell Reports, 2017, 36: 947-957.
15. Zhang GF, Lu TT, Miao WW, Sun LR, Tian M, Wang J, Hao FS*. Genome-wide identification of ABA receptor PYL family and expression analysis of PYLs in response to ABA and osmotic stress in Gossypium. PeerJ, 2017, 5: e4126.
16. Lu TT, Zhang GF, Sun LR, Wang J, Hao FS*. Genome-wide identification of CBL family and expression analysis of CBLs in response to potassium deficiency in cotton. PeerJ, 2017, 5: e3653.
17. Li N, Sun LR, Zhang LY, Song YL, Hu PP, Li C, Hao FS*. AtrbohD and AtrbohF negatively regulate lateral root development by changing the localized accumulation of superoxide in primary roots of Arabidopsis. Planta, 2015, 241: 591-602.
18. Jiao YH, Sun LR, Song YL, Wang LM, Liu LP, Zhang LY, Liu B, Li N, Miao C, Hao FS*. AtrbohD and AtrbohF positively regulate abscisic acid inhibited primary root growth by affecting Ca2+ signaling and auxin response of roots in Arabidopsis. Journal of Experimental Botany, 2013, 64: 4183-4192.
19. Ma LY, Zhang H, Sun LR, Jiao YH, Zhang GZ, Miao C, Hao FS*. NADPH oxidase AtrbohD and AtrbohF function in ROS-dependent regulation of Na+/K+ homeostasis in Arabidopsis under salt stress. Journal of Experimental Botany, 2012, 63: 305-317. ※高被引论文
20. Hao FS, Zhao SL, Dong H, Zhang H, Sun LR, Miao C*. Nia1 and Nia2 are involved in exogenous salicylic acid-induced nitric oxide generation and stomatal closure in Arabidopsis. Journal of Integrative Plant Biology, 2010, 52: 298-307.
21. Sun LR, Hao FS*, Lu BS, Ma LY. AtNOA1 modulates nitric oxide accumulation and stomatal closure induced by salicylic acid in Arabidopsis. Plant Signaling & Behavior, 2010, 5: 1022-1024.
22. 独著《植物气孔生物学》, 第1版, 河南大学出版社, ISBN 978-7-5649-0042-7, 2009年8月出版.
23. 编著《气孔:土壤-植物-大气连续系统的枢纽》第2章, 科学出版社, ISBN 978-7-03-066670-3, 2020年12月出版.
24. 编著《植物生理与分子生物学》第四版第31章, 高等教育出版社, ISBN 9787040351552, 2014年出版.
25. 翻译《植物生理学》第五版第23章, 科学出版社, ISBN 978-7-03-044040-2, 2015年6月出版.
讲授课程:
分子生物学(本科生)
植物生物技术(本科生)
文献阅读(硕、博士生)
植物科学Seminar (硕、博士生)
联系方式:
(1)邮箱:haofsh@henu.edu.cn
(2)通讯地址:河南省开封市河南大学金明校区